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KMID : 0378019860290100119
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New Medical Journal
1986 Volume.29 No. 10 p.119 ~ p.124
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Clinical Study with Oral Gold(Auranofin) in Rheumatoid Arthritis
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Abstract
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Rheumatoid arthritis is an inflammatory disease of unknown etiology that involves the synovial membrane of joints. In some patients it can be a devastating disease that can result in crippling deformities. Chrysotherapy is well established in the management of patients with rheumatoid arthritis who fail to respond to anti-inflammatory drugs alone. Until recently, gold could. only be given parenterally. An orally absorbed gold compound, Auranofin, has been undergoing extensive clinical trials in the last several years.
We studied therapeutic effect of Auranofin in 26 cases at Department of Orthopedic Surgery at Seoul National University Hospital for 15 months from June 1985 to August 1986 and following results were obtained.
1. The ratio between male and female was 1 to 1.9 and 77% of the total cases were in the fifth and sixth decades.
2. Auranofin appeared to have excellent therapeutic effects on rheumatoid arthritis patients, which showed most prominent effect on decreasing the number of tender joints.
3. There was no harmful effect on hematopoietic, renal, and hepatic function after therapy with Auranofin for 12 months.
4. Reduction in ESR was seen in 58% of patients(p<0. 05).
5. Reduction in abnormal rheumatoid factor titers was seen in 22% of patients.
6. Skin lesion was encountered in 14.8% of patients and other complications including digestive system complaints, mucous membrane reactions and alteration in stool pattern were negligible.
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KEYWORD
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